Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance.

ABSTRACT:

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The identification of associations between interleukin-28B (IL-28B) variants and the spontaneous clearance of hepatitis C virus (HCV) raises the issues of causality and the net contribution of host genetics to the trait. To estimate more precisely the net effect of IL-28B genetic variation on HCV clearance, we optimized genotyping and compared the host contributions in multiple- and single-source cohorts to control for viral and demographic effects. The analysis included individuals with chronic or spontaneously cleared HCV infections from a multiple-source cohort (n = 389) and a single-source cohort (n = 71). We performed detailed genotyping in the coding region of IL-28B and searched for copy number variations to identify the genetic variant or haplotype carrying the s

SUBMITTER: di Iulio J 

PROVIDER: S-EPMC3128709 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature