Mesenchymal stem cell stimulation of tissue growth depends on differentiation state.

ABSTRACT: The osteochondral microenvironment involves a complex milieu of cues that facilitate proper tissue development, homeostasis, and repair. This environment is disrupted in disease states such as osteoarthritis. Mesenchymal stem cells (MSCs) are under clinical investigation for the treatment of osteoarthritis given their capacity to differentiate into chondrocytes as well as to secrete a wide array of biologically active factors that support cell proliferation and tissue formation. In fact, the therapeutic action of these cells in many clinical applications is now thought to be at least partially dependent on their secretory capacity. Previous work demonstrated that MSCs were capable of stimulating chondrocyte growth and tissue production, whereas tissue-derived osteoblasts were not stimulato

SUBMITTER: Rothenberg AR 

PROVIDER: S-EPMC3128769 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature