Increased expression of Ero1L-alpha in healing fetal wounds.

ABSTRACT:

Background

Adult mammalian tissues heal injury to the skin with formation of scar; this process quickly seals an injured area, however, excessive scar formation can become a source of persistent pathology, interfering with multiple vital functions. In contrast, mammalian fetal tissue can heal without scar formation. We previously sought to model scarless healing in a rabbit fetal skin wound and identified gene products differentially expressed during fetal wound healing through PCR suppression subtractive hybridization (PCR SSH). One of these transcripts, previously identified simply as clone 11, showed putative increased expression in wounded fetal skin. This study establishes its identity as Ero1L-alpha and confirms its elevated expression in healing fetal wounds.

Findings

SUBMITTER: Gallo PH 

PROVIDER: S-EPMC3128849 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature