A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma.

ABSTRACT:

Background & aims

A single nucleotide polymorphism 61*G (rs4444903) in the epidermal growth factor (EGF) gene has been associated, in 2 case-control studies, with hepatocellular carcinoma (HCC). We tested associations between demographic, clinical, and genetic data and development of HCC, and developed a simple predictive model in a cohort of patients with chronic hepatitis C and advanced fibrosis.

Methods

Black and white subjects from the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) trial (n=816) were followed up prospectively for development of a definite or presumed case of HCC for a median time period of 6.1 years. We used the Cox proportional hazards regression model to determine the hazard ratio for risk of HCC and to develop prediction models.<

SUBMITTER: Abu Dayyeh BK 

PROVIDER: S-EPMC3129453 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature