A statistical framework for biomarker discovery in metabolomic time course data.

ABSTRACT:

Motivation

Metabolomics is the study of the complement of small molecule metabolites in cells, biofluids and tissues. Many metabolomic experiments are designed to compare changes observed over time under two experimental conditions or groups (e.g. a control and drug-treated group) with the goal of identifying discriminatory metabolites or biomarkers that characterize each condition. A common study design consists of repeated measurements taken on each experimental unit thus producing time courses of all metabolites. We describe a statistical framework for estimating time-varying metabolic profiles and their within-group variability and for detecting between-group differences. Specifically, we propose (i) a smoothing splines mixed effects (SME) model that treats each longitudinal me

SUBMITTER: Berk M 

PROVIDER: S-EPMC3129523 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature