Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation.

ABSTRACT:

Background

The rising epidemic of obesity is associated with cognitive decline and is considered as one of the major risk factors for neurodegenerative diseases. Neuroinflammation is a critical component in the progression of several neurological and neurodegenerative diseases. Increased metabolic flux to the brain during overnutrition and obesity can orchestrate stress response, blood-brain barrier (BBB) disruption, recruitment of inflammatory immune cells from peripheral blood and microglial cells activation leading to neuroinflammation. The lack of an effective treatment for obesity-associated brain dysfunction may have far-reaching public health ramifications, urgently necessitating the identification of appropriate preventive and therapeutic strategies. The objective of our st

SUBMITTER: Nerurkar PV 

PROVIDER: S-EPMC3129574 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature