Aromatase inhibitors and antiepileptic drugs: a computational systems biology analysis.

ABSTRACT:

Background

The present study compares antiepileptic drugs and aromatase (CYP19) inhibitors for chemical and structural similarity. Human aromatase is well known as an important pharmacological target in anti-breast cancer therapy, but recent research demonstrates its role in epileptic seizures, as well. The current antiepileptic treatment methods cause severe side effects that endanger patient health and often preclude continued use. As a result, less toxic and more tolerable antiepileptic drugs (AEDs) are needed, especially since every individual responds differently to given treatment options.

Methods

Through a pharmacophore search, this study shows that a model previously designed to search for new classes of aromatase inhibitors is able to identify antiepileptic drugs fr

SUBMITTER: Muftuoglu Y 

PROVIDER: S-EPMC3129585 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature