A comprehensive gene expression atlas of sex- and tissue-specificity in the malaria vector, Anopheles gambiae.

ABSTRACT:

Background

The mosquito, Anopheles gambiae, is the primary vector of human malaria, a disease responsible for millions of deaths each year. To improve strategies for controlling transmission of the causative parasite, Plasmodium falciparum, we require a thorough understanding of the developmental mechanisms, physiological processes and evolutionary pressures affecting life-history traits in the mosquito. Identifying genes expressed in particular tissues or involved in specific biological processes is an essential part of this process.

Results

In this study, we present transcription profiles for ~82% of annotated Anopheles genes in dissected adult male and female tissues. The sensitivity afforded by examining dissected tissues found gene activity in an additional 20% of the g

SUBMITTER: Baker DA 

PROVIDER: S-EPMC3129592 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature