Stimulus-dependent changes in optical responses of the dorsal cochlear nucleus using voltage-sensitive dye.

ABSTRACT: Optical imaging with voltage-sensitive dye was used to examine the spatiotemporal dynamics of stimulus-driven activity on the surface of the dorsal cochlear nucleus (DCN). Stimulation with tones at low to moderate levels produced localized regions of activation that were most commonly elongated rostrocaudally. The size of these activation areas expanded with increases in sound level, while their centers shifted from the lateral direction to the medial direction with increases in stimulus frequency. In contrast to the tonotopic patterns of activation evoked by tones, electrical stimulation of the DCN surface resulted in bands of activation that were elongated along the medial-lateral axis; response latencies increased with distance along these bands from the point of stimulation. Shifting t

SUBMITTER: Licari FG 

PROVIDER: S-EPMC3129723 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature