Frequency of genetic polymorphisms of PXR gene in the Brazilian population.

ABSTRACT:

Introduction

PXR polymorphisms have been implicated in modulating CYP3A4 and PXR expression, potentially accounting for interindividual differences in drug metabolism. The prevalence of PXR polymorphisms varies among ethnic groups and data on the allelic distribution in the highly mixed Brazilian population is lacking. The aim of this study was to analyze genetic variations in the PXR gene in Brazilians and to compare the results to other ethnic groups.

Methods

DNA samples from 117 healthy Brazilians underwent PCR amplification and sequencing.

Results

Eleven polymorphisms were identified, 3 of which are highly associated with differences in CYP3A4 expression. We also identified 1 new synonymous variant in 1.3% of the alleles. Among the functional polymorphisms, -25913

SUBMITTER: Moreira RP 

PROVIDER: S-EPMC3129971 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature