The Impact of Preeclampsia on Gene Expression at the Maternal-Fetal Interface.

ABSTRACT: Preeclampsia (PE) impacts 8 million mother-infant pairs worldwide each year. This human pregnancy-specific disease characterized by hypertension and proteinuria accounts for significant maternal and neonatal morbidity and mortality. The current theory of the pathogenesis of PE as reviewed by Drs. Christopher Redman and Ian Sargent is thought to occur as a 2-stage process with poor placentation in the first half of pregnancy resulting in the maternal response in the second half of pregnancy. Our studies have focused on understanding the placental contribution to this serious disease by examining the gene expression profile of the deciduas basalis or basal plate, the region of the placenta involved in the "poor placentation". In this review we present summaries of our microarray datasets bot

SUBMITTER: Winn VD 

PROVIDER: S-EPMC3129988 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature