Duodenal ulcer promoting gene of Helicobacter pylori.

ABSTRACT:

Background & aims

Identification of a disease-specific H pylori virulence factors predictive of the outcome of infection remains unachieved.

Methods

We used the polymerase chain reaction and Southern blot to compare the presence of 14 vir homologue genes with clinical presentation of H pylori infection, mucosal histology, and mucosal interleukin (IL)-8 levels.

Results

We examined 500 H pylori strains from East Asia and South America, including 120 with gastritis, 140 with duodenal ulcer (DU), 110 with gastric ulcer (GU), and 130 with gastric cancer. Only 1 gene that encompassed both jhp0917 and jhp0918 called dupA (duodenal ulcer promoting gene) was associated with a specific clinical outcome. dupA was present in 42% of DU vs. 21% of gastritis (adjusted odds ratio [OR

SUBMITTER: Lu H 

PROVIDER: S-EPMC3130061 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature