Relationships among health-related quality of life, pulmonary health, and newborn screening for cystic fibrosis.

ABSTRACT:

Background

The objective of this study was to examine relationships between pulmonary health and health-related quality of life (HRQOL) in patients with cystic fibrosis (CF) evaluated longitudinally in the Wisconsin Newborn Screening Project.

Methods

Patients aged 8 to 18 years (mean ± SD, 13.5 ± 2.8) in early diagnosis (n = 45) and control (n = 50) groups completed Cystic Fibrosis Questionnaires (CFQs) to measure HRQOL at three data points over a 2-year period. Pulmonary health was evaluated concurrently by the Wisconsin chest x-ray scoring system (WCXR) and pulmonary function tests (PFTs).

Results

WCXR showed significant group differences (P ≤ .023), with the early diagnosis group showing more-severe lung disease. When adjusted for group differences in mucoid Pseudo

SUBMITTER: Tluczek A 

PROVIDER: S-EPMC3130527 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature