Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques.

ABSTRACT: Integrative genomics and genetics approaches have proven to be a useful tool in elucidating the complex relationships often found in gene regulatory networks. More importantly, a number of studies have provided the necessary experimental evidence confirming the validity of the causal relationships inferred using such an approach. By integrating messenger RNA (mRNA) expression data with microRNA (miRNA) (i.e. small non-coding RNA with well-established regulatory roles in a myriad of biological processes) expression data, we show how integrative genomics approaches can be used to characterize the role played by approximately a third of registered mouse miRNAs within the context of a liver gene regulatory network. Our analysis reveals that the transcript abundances of miRNAs are subject to re

SUBMITTER: Su WL 

PROVIDER: S-EPMC3130556 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature