Effects of in vitro adult platelet transfusions on neonatal hemostasis.

ABSTRACT:

Background

Thrombocytopenia is frequent among neonates, and 20-25% of affected infants are treated with platelet transfusions. These are frequently given for mild thrombocytopenia (platelets: 50-100 × 10(9) L(-1)), largely because of the known hyporeactivity of neonatal platelets. In tests of primary hemostasis, however, neonates have shorter bleeding and closure times (CTs) than adults. This has been attributed to their higher hematocrits, higher von Willebrand factor (VWF) concentrations, and predominance of longer VWF polymers.

Objective

To determine whether the 'transfusion' of adult (relatively hyperreactive) platelets into neonatal blood results in a hypercoagulable profile.

Methods

Cord blood (CB) and adult peripheral blood (PB) were separated (with a modified

SUBMITTER: Ferrer-Marin F 

PROVIDER: S-EPMC3130591 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature