Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression.

ABSTRACT:

Background

Gliomas are thought to form by clonal expansion from a single cell-of-origin, and progression-associated mutations to occur in its progeny cells. Glioma progression is associated with elevated growth factor signaling and loss of function of tumor suppressors Ink4a, Arf and Pten. Yet, gliomas are cellularly heterogeneous; they recruit and trap normal cells during infiltration.

Methodology/principal findings

We performed lineage tracing in a retrovirally mediated, molecularly and histologically accurate mouse model of hPDGFb-driven gliomagenesis. We were able to distinguish cells in the tumor that were derived from the cell-of-origin from those that were not. Phenotypic, tumorigenic and expression analyses were performed on both populations of these cells. Here we s

SUBMITTER: Fomchenko EI 

PROVIDER: S-EPMC3130733 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature