Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans.

ABSTRACT: Chemotherapeutic agents are used in the treatment of many cancers, yet variable resistance and toxicities among individuals limit successful outcomes. Several studies have indicated outcome differences associated with ancestry among patients with various cancer types. Using both traditional SNP-based and newly developed gene-based genome-wide approaches, we investigated the genetics of chemotherapeutic susceptibility in lymphoblastoid cell lines derived from 83 African Americans, a population for which there is a disparity in the number of genome-wide studies performed. To account for population structure in this admixed population, we incorporated local ancestry information into our association model. We tested over 2 million SNPs and identified 325, 176, 240, and 190 SNPs that were sugge

SUBMITTER: Wheeler HE 

PROVIDER: S-EPMC3130766 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature