The molecular biology of human herpesvirus-6 latency and telomere integration.

ABSTRACT: The genomes of herpesviruses establish latency as a circular episome. However, Human herpesvirus-6 (HHV-6) has been shown to specifically integrate into the telomeres of chromosomes during latency and vertically transmit through the germ-line. This review will focus on the telomere integration of HHV-6, the potential viral and cellular genes that mediate integration, and the clinical impact on the host.

SUBMITTER: Arbuckle JH 

PROVIDER: S-EPMC3130849 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature