Genetic Polymorphism of FLG in Korean Ichthyosis Vulgaris Patients.

ABSTRACT:

Background

Filaggrin is a key protein that facilitates the formation of skin barrier by forming a stratum corneum. Mutations in the gene encoding filaggrin (FLG) have recently been reported in patients with ichthyosis vulgaris (IV). Interestingly, there are ethnic differences between FLG mutations identified in Asians and Europeans, and few FLG mutations are overlapping between Chinese and Japanese IV patients.

Objective

The aim of this study was to investigative the genetic polymorphism of FLG in Korean IV patients.

Methods

Genomic DNA was extracted from whole venous blood specimen of Korean patients with IV and a control group, and the full sequence of FLG was determined via overlapping long-range polymerase chain reaction method.

Results

Analysis of base seq

SUBMITTER: Kim EJ 

PROVIDER: S-EPMC3130859 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature