Screening for celiac disease in a North American population: sequential serology and gastrointestinal symptoms.

ABSTRACT:

Objectives

The prevalence of diagnosed celiac disease is <1 in 2,000 in the United States, but screening studies undertaken in European and other populations have revealed a much higher prevalence. The objective of this study was to determine the prevalence of celiac disease and the utility of screening in the general adult population of a geographically isolated area.

Methods

Serum tissue transglutaminase antibodies (tTG-IgA) were measured in volunteer health-care participants aged ≥ 18 years at the annual Casper, Wyoming, Blue Envelope Health Fair blood draw. Subjects with positive tTG-IgA tests had their endomysial IgA antibodies checked. Double positives were offered endoscopy with small bowel biopsy. All subjects completed a short gastrointestinal (GI) symptom questionn

SUBMITTER: Katz KD 

PROVIDER: S-EPMC3130886 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature