IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children.

ABSTRACT:

Background

Apolipoprotein E (APOE) genotype (ε2/ε3/ε4: rs429358 ε4 allele; rs7412 ε2 allele) is strongly associated with both lipid levels and Alzheimer's disease. Although there is also evidence of milder cognitive impairment in later life in carriers of the APOE ε4 allele, there have been few studies investigating the impact of APOE genotype on cognitive function in children.

Methods

We determined APOE genotype in 5995 children from the Avon Longitudinal Study of Parents and Children and investigated associations between APOE genotype and plasma lipids (at age 9), IQ (at age 8), memory (at ages 8 and 10), and performance in school attainment tests (at ages 7, 11, and 14).

Results

Observed genotype group counts were consistent with Hardy-Weinberg equilibrium (χ(2)p v

SUBMITTER: Taylor AE 

PROVIDER: S-EPMC3130925 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature