Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain.

ABSTRACT: Forkhead-box protein P2 is a transcription factor that has been associated with intriguing aspects of cognitive function in humans, non-human mammals, and song-learning birds. Heterozygous mutations of the human FOXP2 gene cause a monogenic speech and language disorder. Reduced functional dosage of the mouse version (Foxp2) causes deficient cortico-striatal synaptic plasticity and impairs motor-skill learning. Moreover, the songbird orthologue appears critically important for vocal learning. Across diverse vertebrate species, this well-conserved transcription factor is highly expressed in the developing and adult central nervous system. Very little is known about the mechanisms regulated by Foxp2 during brain development. We used an integrated functional genomics strategy to robustly defin

SUBMITTER: Vernes SC 

PROVIDER: S-EPMC3131290 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature