Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform.

ABSTRACT: Efforts to extend nanoparticle residence time in vivo have inspired many strategies in particle surface modifications to bypass macrophage uptake and systemic clearance. Here we report a top-down biomimetic approach in particle functionalization by coating biodegradable polymeric nanoparticles with natural erythrocyte membranes, including both membrane lipids and associated membrane proteins for long-circulating cargo delivery. The structure, size and surface zeta potential, and protein contents of the erythrocyte membrane-coated nanoparticles were verified using transmission electron microscopy, dynamic light scattering, and gel electrophoresis, respectively. Mice injections with fluorophore-loaded nanoparticles revealed superior circulation half-life by the erythrocyte-mimicking nanopart

SUBMITTER: Hu CM 

PROVIDER: S-EPMC3131364 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature