White matter deterioration in 15 months: latent growth curve models in healthy adults.

ABSTRACT: The goal of the study was to examine the differences in trajectories of change in the volume of white matter hyperintensities (WMH) in healthy adults within a relatively short period. We measured volumes of periventricular and deep WMH in frontal, temporal, parietal, and occipital lobes of healthy volunteers (age 49-83) on 3 occasions, approximately 15 months apart. At baseline, 40 participants underwent magnetic resonance imaging (MRI), 37 returned for the first and 30 for the second follow-up. Latent growth curve models estimated the variance and mean change in WMH volume and examined their associations with age, sex, education, and hypertension. In both regions and for both WMH types, the positive association between volume and age was stronger among the middle-aged adults and became we

SUBMITTER: Raz N 

PROVIDER: S-EPMC3131417 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature