MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin.

ABSTRACT:

Purpose

The type I Melanoma Antigen GEnes (MAGEs) are commonly expressed in cancers, fueling speculation that they may be therapeutic targets with oncogenic potential. They form complexes with RING domain proteins that have E3 ubiquitin ligase activity and promote p53 degradation. MAGE-A3 was detected in tumor specimens from patients with multiple myeloma and its expression correlated with higher frequencies of Ki-67(+) malignant cells. In this report, we examine the mechanistic role of MAGE-A in promoting survival of proliferating multiple myeloma cells.

Experimental design

The impact of MAGE-A3 expression on survival and proliferation in vivo was examined by immunohistochemical analysis in an independent set of tumor specimens segregated into two groups: newly diagnosed, u

SUBMITTER: Nardiello T 

PROVIDER: S-EPMC3131419 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature