Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.

ABSTRACT:

Purpose

Inflammation occurs routinely when managing gliomas and is not easily distinguishable from tumor regrowth by current MRI methods. The lack of noninvasive technologies that monitor inflammation prevents us to understand whether it is beneficial or detrimental for the patient, and current therapies do not take this host response in consideration. We aim to establish whether a gadolinium (Gd)-based agent targeting the inflammatory enzyme myeloperoxidase (MPO) can selectively detect intra- and peritumoral inflammation as well as glioma response to treatment by MRI.

Methods

We carried out serial Gd-bis-5-HT-DTPA (MPO-Gd) MRI before and after treating rodent gliomas with different doses of oncolytic virus (OV) and analyzed animal survival. The imaging results were compared

SUBMITTER: Kleijn A 

PROVIDER: S-EPMC3131449 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature