Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis.

ABSTRACT: For the last decade, worldwide efforts for the treatment of anthrax infection have focused on developing effective vaccines. Patients that are already infected are still treated traditionally using different types of standard antimicrobial agents. The most popular are antibiotics such as tetracyclines and fluoroquinolones. While aminoglycosides appear to be less effective antimicrobial agents than other antibiotics, synthetic aminoglycosides have been shown to act as potent inhibitors of anthrax lethal factor and may have potential application as antitoxins. Here, we present a structural analysis of the BA2930 protein, a putative aminoglycoside acetyltransferase, which may be a component of the bacterium's aminoglycoside resistance mechanism. The determined structures revealed details of a

SUBMITTER: Klimecka MM 

PROVIDER: S-EPMC3131501 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature