Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer.

ABSTRACT: Alterations in microRNAs expression have been proposed to play role in endometrial cancer pathogenesis. Dicer and Drosha are main regulators of microRNA biogenesis and deregulation of their expression has been indicated as a possible cause of microRNAs alterations observed in various cancers. The objective of this study was to investigate Dicer and Drosha genes expression in endometrial cancer and to analyze the impact of clinicopathological characteristics on their expression. Fresh tissue samples were collected from 44 patients (26 endometroid endometrial carcinoma and 18 controls). Clinical and pathological data were acquired from medical documentation. Dicer and Drosha genes expressions were assessed by qRT-PCR using validated reference genes. Dicer and Drosha expression levels were si

SUBMITTER: Torres A 

PROVIDER: S-EPMC3131523 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature