Caspase-3-dependent export of TCTP: a novel pathway for antiapoptotic intercellular communication.

ABSTRACT: The apoptotic program incorporates a paracrine component of importance in fostering tissue repair at sites of apoptotic cell deletion. As this paracrine pathway likely bears special importance in maladaptive intercellular communication leading to vascular remodeling, we aimed at further defining the mediators produced by apoptotic endothelial cells (EC), using comparative and functional proteomics. Apoptotic EC were found to release nanovesicles displaying ultrastructural characteristics, protein markers and functional activity that differed from apoptotic blebs. Tumor susceptibility gene 101 and translationally controlled tumor protein (TCTP) were identified in nanovesicle fractions purified from medium conditioned by apoptotic EC and absent from purified apoptotic blebs. Immunogold label

SUBMITTER: Sirois I 

PROVIDER: S-EPMC3131994 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature