Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine.

ABSTRACT:

Introduction

Glucosamine is an amino-monosaccharide and precursor of glycosaminoglycans, major components of joint cartilage. Glucosamine has been clinically introduced for the treatment of osteoarthritis but the data about its protective role in disease are insufficient. The goal of this study was to investigate the effect of long term administration of glucosamine on bone resorption and remodeling.

Methods

The effect of glucosamine on bone resorption and remodeling was studied in a model of collagenase-induced osteoarthritis (CIOA). The levels of macrophage-inflammatory protein (MIP)-1α, protein regulated upon activation, normal T-cell expressed, and secreted (RANTES), soluble receptor activator of nuclear factor kappa-B ligand (RANKL), tumor necrosis factor (TNF)-α, and i

SUBMITTER: Ivanovska N 

PROVIDER: S-EPMC3132029 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature