Close 3D proximity of evolutionary breakpoints argues for the notion of spatial synteny.

ABSTRACT:

Background

Folding and intermingling of chromosomes has the potential of bringing close to each other loci that are very distant genomically or even on different chromosomes. On the other hand, genomic rearrangements also play a major role in the reorganisation of loci proximities. Whether the same loci are involved in both mechanisms has been studied in the case of somatic rearrangements, but never from an evolutionary standpoint.

Results

In this paper, we analysed the correlation between two datasets: (i) whole-genome chromatin contact data obtained in human cells using the Hi-C protocol; and (ii) a set of breakpoint regions resulting from evolutionary rearrangements which occurred since the split of the human and mouse lineages. Surprisingly, we found that two loci distan

SUBMITTER: Veron AS 

PROVIDER: S-EPMC3132170 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature