Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.

ABSTRACT:

Background

Current biomarkers for breast cancer have little potential for detection. We determined whether breast cancer subtypes influence circulating protein biomarkers.

Methods

A sandwich ELISA microarray platform was used to evaluate 23 candidate biomarkers in plasma samples that were obtained from subjects with either benign breast disease or invasive breast cancer. All plasma samples were collected at the time of biopsy, after a referral due to a suspicious screen (e.g., mammography). Cancer samples were evaluated on the basis of breast cancer subtypes, as defined by the HER2 and estrogen receptor statuses.

Results

Ten proteins were statistically altered in at least one breast cancer subtype, including four epidermal growth factor receptor ligands, two matrix me

SUBMITTER: Gonzalez RM 

PROVIDER: S-EPMC3132300 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature