PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase.

ABSTRACT: The protein tyrosine phosphatase PTPL1/PTPN13, the activity of which is decreased through allelic loss, promoter methylation, or somatic mutations in some tumors, has been proposed as a tumor suppressor gene. Moreover, our recent clinical study identified PTPL1 expression level as an independent prognostic indicator of a favorable outcome for patients with breast cancer. However, how PTPL1 can affect tumor aggressiveness has not been characterized. Here, we first show that PTPL1 expression, assessed by immunohistochemistry, is decreased in breast cancer and metastasis specimens compared with nonmalignant tissues. Second, to evaluate whether PTPL1 plays a critical role in breast cancer progression, RNA interference experiments were performed in poorly tumorigenic MCF-7 breast cancer cells.

SUBMITTER: Glondu-Lassis M 

PROVIDER: S-EPMC3132424 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature