High fat diet reduces the expression of glutathione peroxidase 3 in mouse prostate.

ABSTRACT:

Background

High fat diets are known to be a risk factor for prostate cancer. In this study, we investigated the effect of high fat diet on mouse prostate gene expression.

Methods

C57BL/6J mice were fed either a control or high fat diet for 12 weeks. Microarray analyses were performed on mouse ventral prostate (VP) and dorsolateral prostate (DLP), followed by canonical pathway analysis and regulatory network identification. mRNA changes were confirmed by real time PCR.

Results

Approximately 2,125, and 1,194 genes responded significantly to the high fat diet in VP, DLP, respectively. Pathways and networks related to oxidative stress, glutathione metabolism, NRF-mediated oxidative stress response and NF-kappaB were all differentially regulated by high fat diet. Glutathio

SUBMITTER: Sekine Y 

PROVIDER: S-EPMC3132426 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature