Interleukin-6 (-636 c/g) gene polymorphism in korean children with kawasaki disease.

ABSTRACT:

Background and objectives

Kawasaki disease (KD) is a multi-systemic vasculitis with coronary artery involvement. Serum interleukin (IL)-6 levels during acute phase showed a significant correlation with the duration of fever in patients with KD who were not treated with intravenous immunoglobulin (IVIG), suggesting that the regulation of IL-6 expression in KD patients may differ from that in normal children. However, there are controversies surrounding the association between IL-6 (-636 C/G) gene polymorphism and development of KD.

Subjects and methods

One hundred and nine children with KD and 191 children with congenital heart disease were included in this study. Echocardiography was performed to examine cardiac involvement in patients with KD. Genotyping of the IL-6 (-636 C

SUBMITTER: Ahn HM 

PROVIDER: S-EPMC3132694 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature