Synthesis of spiro-fused pyrazolidoylisoxazolines.

ABSTRACT: Routes to structurally unique spiro-fused pyrazolidoylisoxazolines are reported. These methods start with monosubstituted hydrazines or hydrazides and utilize the nitrile oxide 1,3-dipolar cycloaddition reaction to generate the targeted spiro-fused bis-heterocycles. Molecular shape space diversity analyses were performed on these pyrazolidoylisoxazolines showing that manipulation of the appended R groups significantly changes the molecular shape.

SUBMITTER: Guggenheim KG 

PROVIDER: S-EPMC3132818 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature