Capitalizing on admixture in genome-wide association studies: a two-stage testing procedure and application to height in African-Americans.

ABSTRACT: As genome-wide association studies expand beyond populations of European ancestry, the role of admixture will become increasingly important in the continued discovery and fine-mapping of variation influencing complex traits. Although admixture is commonly viewed as a confounding influence in association studies, approaches such as admixture mapping have demonstrated its ability to highlight disease susceptibility regions of the genome. In this study, we illustrate a powerful two-stage testing strategy designed to uncover trait-associated single nucleotide polymorphisms in the presence of ancestral allele frequency differentiation. In the first stage, we conduct an association scan by using predicted genotypic values based on regional admixture estimates. We then select a subset of promisin

SUBMITTER: Kang G 

PROVIDER: S-EPMC3132882 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature