Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake.

ABSTRACT:

Background

Resonance Raman spectroscopy (RRS) has been suggested as a feasible method for noninvasive carotenoid measurement of human skin. However, before RRS measures of dermal carotenoids can be used as a biomarker, data on intra- and intersubject variability and validity are needed.

Objective

The purpose of this study was to evaluate the reproducibility and validity of RRS measures of dermal total carotenoids and lycopene in humans.

Design

In study 1, 74 men and women with diverse skin pigmentation were recruited. RRS measures of the palm, inner arm, and outer arm were obtained at baseline, 1 wk, 2 wk, 1 mo, 3 mo, and 6 mo (to maximize seasonal variation). The RRS device used visible light at 488 nm to estimate total carotenoids and at 514 nm to estimate lycopene.

SUBMITTER: Mayne ST 

PROVIDER: S-EPMC3133234 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature