Cardiac β-adrenoceptor expression is markedly depressed in Ossabaw swine model of cardiometabolic risk.

ABSTRACT: Ossabaw swine have a "thrifty genotype" and consumption of excess calories induces many classical components of the metabolic syndrome, including obesity, insulin resistance, impaired glucose tolerance, dyslipidemia, hyperleptinemia, and hypertension. Earlier studies indicate that the metabolic syndrome is associated with diminished cardiac function; however, to what degree this impairment is associated with alterations in myocardial β(1)- and β(2)-adrenoceptor (AR) expression has not been fully elucidated. Accordingly, the present study was designed to investigate the effects of the metabolic syndrome on cardiac β(1)- and β(2)-AR expression. Studies were conducted on left ventricular tissue samples obtained from control lean and chronically (50 weeks) high-fat-fed obese animals. Chronic f

SUBMITTER: Dincer UD 

PROVIDER: S-EPMC3133518 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature