Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival.

ABSTRACT:

Background

Raf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival pathways. RKIP activity is modulated in part by phosphorylation on Serine 153 by protein kinase C, which leads to dissociation of RKIP from Raf-1. RKIP expression is low in many human cancers and represents an indicator of poor prognosis and/or induction of metastasis. The prognostic power has typically been based on total RKIP expression and has not considered the significance of phospho-RKIP.

Methods

The present study examined the expression levels of both RKIP and phospho-RKIP in human lung cancer tissue microarray proteomics technology.

Results

Total RKIP and phospho-RKIP expression levels were similar in normal and cancerous tissues. phospho-

SUBMITTER: Huerta-Yepez S 

PROVIDER: S-EPMC3134426 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature