Fatty acid binding protein 4 regulates intracellular lipid accumulation in human trophoblasts.

ABSTRACT:

Context

Maternal obesity, gestational diabetes (GDM), or type 2 diabetes (T2DM) is associated with altered lipid metabolism and fetal overgrowth.

Objective

The objective of the study was to test the hypothesis that hyperlipidemia and hyperinsulinemia regulate lipid content and expression of lipid-trafficking proteins in human placental trophoblasts.

Study design

Pregnant women were prospectively enrolled for clinical specimens collection, and cultured human trophoblasts were used for experiments.

Setting

This was a translational study conducted at an academic biomedical research center.

Patients or other participants

Normal weight, obese, or obese with gestational diabetes or type 2 diabetes pregnant women (n = 10 in each group) undergoing scheduled cesa

SUBMITTER: Scifres CM 

PROVIDER: S-EPMC3135200 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature