IgG4-related hypophysitis: a new addition to the hypophysitis spectrum.

ABSTRACT:

Context

Hypophysitis is a chronic inflammation of the pituitary gland that comprises an increasingly complex clinicopathological spectrum. Within this spectrum, lymphocytic and granulomatous hypophysitis are the most common forms, but newer variants have recently been reported.

Objective

The aims of the study were to describe a new patient with IgG4-related hypophysitis, review the published literature, and provide diagnostic criteria.

Setting

A 75-yr-old man presented with a 1-yr history of frontal headache. Initial studies revealed panhypopituitarism and a mass in both the sella turcica and the sphenoidal sinus. The patient underwent transphenoidal surgery, initiated high-dose prednisone followed by hormone replacement therapy, and was closely monitored for 3 yr.

SUBMITTER: Leporati P 

PROVIDER: S-EPMC3135201 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature