Dominant suppression of Addison's disease associated with HLA-B15.

ABSTRACT:

Context

Autoimmune Addison's disease (AD) is the major cause of primary adrenal failure in developed nations. Autoantibodies to 21-hydroxylase (21OH-AA) are associated with increased risk of progression to AD. Highest genetic risk is associated with the Major Histocompatibility region (MHC), specifically human leukocyte antigen (HLA)-DR3 haplotypes (containing HLA-B8) and HLA-DR4.

Objective

The objective of the study was the further characterization of AD risk associated with MHC alleles.

Design, setting, and participants

MHC genotypes were determined for HLA-DRB1, DQA1, DQB1, MICA, HLA-B, and HLA-A in 168 total individuals with 21OH-AA (85 with AD at referral and 83 with positive 21OH-AA but without AD at referral).

Main outcome measure(s)

Genotype was evaluat

SUBMITTER: Baker PR 

PROVIDER: S-EPMC3135206 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature