Transcriptional responses of cultured rat sympathetic neurons during BMP-7-induced dendritic growth.

ABSTRACT:

Background

Dendrites are the primary site of synapse formation in the vertebrate nervous system; however, relatively little is known about the molecular mechanisms that regulate the initial formation of primary dendrites. Embryonic rat sympathetic neurons cultured under defined conditions extend a single functional axon, but fail to form dendrites. Addition of bone morphogenetic proteins (BMPs) triggers these neurons to extend multiple dendrites without altering axonal growth or cell survival. We used this culture system to examine differential gene expression patterns in naïve vs. BMP-treated sympathetic neurons in order to identify candidate genes involved in regulation of primary dendritogenesis.

Methodology/principal findings

To determine the critical transcriptional win

SUBMITTER: Garred MM 

PROVIDER: S-EPMC3135585 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature