Association between somatostatin receptor 5 gene polymorphisms and pancreatic cancer risk and survival.

ABSTRACT:

Background

Somatostatin (SST) inhibited cell proliferation and negatively regulated the release of growth hormones by means of specific receptors (SSTR). Genetic variation in SSTR had been associated with risk of human cancers but had never been investigated in pancreatic cancer.

Methods

In this retrospective study the SSTR5 gene in paired tumor and blood samples from 33 pancreatic adenocarcinoma patients using the Sanger method were sequenced. Three single nucleotide polymorphisms (SNPs) in samples from 863 patients with pancreatic ductal adenocarcinoma and 876 healthy controls using the TaqMan method were analyzed. The associations between gene polymorphisms and pancreatic cancer risk and survival were analyzed by multivariate logistic regression and Cox proportional hazar

SUBMITTER: Li D 

PROVIDER: S-EPMC3135720 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature