Hemoglobin level in older persons and incident Alzheimer disease: prospective cohort analysis.

ABSTRACT:

Objective

To test the hypothesis that level of hemoglobin is associated with incident Alzheimer disease (AD).

Methods

A total of 881 community-dwelling older persons participating in the Rush Memory and Aging Project without dementia and a measure of hemoglobin level underwent annual cognitive assessments and clinical evaluations for AD.

Results

During an average of 3.3 years of follow-up, 113 persons developed AD. In a Cox proportional hazards model adjusted for age, sex, and education, there was a nonlinear relationship between baseline level of hemoglobin such that higher and lower levels of hemoglobin were associated with AD risk (hazard ratio [HR] for the quadratic of hemoglobin 1.06, 95% confidence interval [CI] 1.01-1.11). Findings were unchanged after controll

SUBMITTER: Shah RC 

PROVIDER: S-EPMC3136057 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature