Nontraditional risk factors combine to predict Alzheimer disease and dementia.

ABSTRACT:

Objective

To investigate whether dementia risk can be estimated using only health deficits not known to predict dementia.

Methods

A frailty index consisting of 19 deficits not known to predict dementia (the nontraditional risk factors index [FI-NTRF]) was constructed for 7,239 cognitively healthy, community-dwelling older adults in the Canadian Study of Health and Aging. From baseline, their 5-year and 10-year risks for Alzheimer disease (AD), dementia of all types, and survival were estimated.

Results

The FI-NTRF was closely correlated with age (r2 > 0.96, p < 0.001). The incidence of AD and dementia increased exponentially with the FI-NTRF (r2 > 0.75, p < 0.001 over 10 years). Adjusted for age, sex, education, and baseline cognition, the odds ratio of dementia incre

SUBMITTER: Song X 

PROVIDER: S-EPMC3136058 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature