RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape.

ABSTRACT: The intracellular localization and shape of the nucleus plays a central role in cellular and developmental processes. In fibroblasts, nuclear movement and shape are controlled by a specific perinuclear actin network made of contractile actin filament bundles called transmembrane actin-associated nuclear (TAN) lines that form a structure called the actin cap. The identification of regulatory proteins associated with this specific actin cytoskeletal dynamic is a priority for understanding actin-based changes in nuclear shape and position in normal and pathological situations. Here, we first identify a unique family of actin regulators, the refilin proteins (RefilinA and RefilinB), that stabilize specifically perinuclear actin filament bundles. We next identify the actin-binding filamin A (FL

SUBMITTER: Gay O 

PROVIDER: S-EPMC3136255 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature