Identification of radiation-induced expression changes in nonimmortalized human T cells.

ABSTRACT: In the event of a radiation accident or attack, it will be imperative to quickly assess the amount of radiation exposure to accurately triage victims for appropriate care. RNA-based radiation dosimetry assays offer the potential to rapidly screen thousands of individuals in an efficient and cost-effective manner. However, prior to the development of these assays, it will be critical to identify those genes that will be most useful to delineate different radiation doses. Using global expression profiling, we examined expression changes in nonimmortalized T cells across a wide range of doses (0.15-12 Gy). Because many radiation responses are highly dependent on time, expression changes were examined at three different times (3, 8, and 24 h). Analyses identified 61, 512 and 1310 genes with si

SUBMITTER: Pogosova-Agadjanyan EL 

PROVIDER: S-EPMC3136539 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature