Active and passive cigarette smoking and acute lung injury after severe blunt trauma.

ABSTRACT:

Rationale

Cigarette smoking has been demonstrated in laboratory studies to have effects on lung epithelial and endothelial function similar to those observed in acute lung injury (ALI). However, the association between active and passive cigarette smoke exposure and susceptibility to ALI has not been prospectively studied.

Objectives

We hypothesized that both active and passive cigarette smoke exposure would be associated with increased susceptibility to ALI after severe blunt trauma.

Methods

We measured levels of cotinine, a metabolite of nicotine and validated biomarker of tobacco use, in plasma samples obtained immediately on arrival at the emergency department from 144 adult subjects after severe blunt trauma. Patients were then followed for the development of ALI

SUBMITTER: Calfee CS 

PROVIDER: S-EPMC3136993 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature